| abstract |
The present invention provides an enhanced oncolytic adenovirus and its application. On the basis of chimpanzee adenovirus AdC68, the present inventors established a composite oncolytic adenovirus by combining the characteristics of the virus itself and immune checkpoints. The compound oncolytic adenovirus has good specificity, good targeting and safety, can achieve intratumoral administration, avoid systemic administration, can achieve high-efficiency antitumor effects while attenuating toxic and side effects, Reduce dosage or cost of medication. At the same time, the composite oncolytic adenovirus can significantly inhibit tumors and has strong killing ability. |