| abstract |
The invention belongs to the technical field of biomedicine, and in particular relates to a tumor hyperpermeable polymer for graded drug release and a preparation method and application thereof. The polymer is made of maleimide-polyethylene glycol, polyaspartic acid-grafted polyethyleneimine, polylysine-grafted benzaldehyde, and its size is small, and each block is mutually The synergistic effect of penetrating tumor tissue and aggregation is achieved; further loading and binding of anti-tumor small molecule inhibitors, antibodies and small interfering RNA can reduce the paracrine secretion of collagen matrix, increase tumor infiltration of killer immune cells, and reduce the amount of glucose. The uptake amount can increase the glucose content of the tumor microenvironment, and finally achieve the effect of significantly improving the tumor microenvironment and treating the tumor. |