| abstract |
The invention discloses a long-acting antibacterial and anticoagulant material, a preparation method and application thereof, and relates to the technical field of medical materials. The long-acting antibacterial and anticoagulant material includes a substrate, the substrate is coated with a Cu-MOFs coating, and the Cu-MOFs coating is loaded with nitric oxide. The Cu-MOFs coating loaded with NO gas was prepared by loading nitric oxide in the Cu-MOFs coating. The NO loaded in the Cu-MOFs coating can be released synergistically with Cu 2+ within the safe and physiological range of the human body, and realize the high-efficiency antibacterial effect of medical materials in the early stage of implantation; the Cu-MOFs coating can also in situ catalyze endogenous NO. The donor releases NO, which greatly prolongs the release time of NO on the surface of the material. In addition, the massive release of NO supported in the initial stage and the sequential release behavior of the NO donor catalyzed by Cu(II) in the later stage can achieve long-term and stable NO release from medical materials, and the release period can reach 30 days. |