http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114409740-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_acaa96e71ca48522b1b8c8ffe50e1007 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_289b27060c4068b6527059ac84bd9413 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-16 |
| filingDate | 2021-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc50c24b808d44ee74eccfceb484bfa7 |
| publicationDate | 2022-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114409740-A |
| titleOfInvention | A kind of method for purifying desmopressin impurities |
| abstract | The present invention is a method for purifying impurities of desmopressin. The impurities of desmopressin mainly include the following steps: using desmopressin linear peptide as a raw material to produce desmopressin obtained by ring destruction reaction. Vasopressin impurity dimer; use tetraalkylsilane bonded silica gel filler as stationary phase, use phosphoric acid as mobile phase A, and use acetonitrile as mobile phase B for the first HPLC purification to remove desmopressin impurities The first step sample solution of desmopressin impurity peptide is obtained by removing the solvent; freeze-drying to purify the desmopressin impurity. The method of the invention adopts the combination of tetraalkylsilane-bonded silica gel filler and mobile phase phosphoric acid, which can remove most impurities and fragment impurities of desmopressin impurities; the purity of the collected samples reaches 95%. The purity and yield of the desmopressin impurity product are effectively improved. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-116023441-A |
| priorityDate | 2021-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 65.