| abstract |
The invention discloses an aptamer-cyclometalated iridium conjugate as well as a preparation method and application thereof. An aptamer-cyclometalated iridium conjugate comprising at least one of the following structural formulae: aprirc 1, aprirc 2, aprirc 3, and aprirc 4; wherein, the aptamer in the structural formula is AS1411 aptamer. The aptamer-cyclometalated iridium conjugate has an excellent inhibition effect on tumor cell strains such as lung cancer cells A549, cervical cancer cells HeLa, liver cancer cells HepG2, breast cancer cells MCF-7 and the like, has low toxicity on normal cells, can be specifically combined with the cancer cells, and can be applied to fluorescence imaging and antitumor drugs. |