http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114409631-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_180f7c58622a8c001dcd79281ef831c9 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 |
| filingDate | 2022-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_529ec7e02b114da5b23b21dc080d395f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_619a09427dc14379d090b095d7eecce4 |
| publicationDate | 2022-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114409631-A |
| titleOfInvention | Preparation method of esomeprazole impurity H431/41 |
| abstract | The invention discloses a preparation method of an esomeprazole impurity H431/41, which comprises the following steps: esomeprazole is degraded by hydrochloric acid at room temperature (20-25 ℃) to generate 8- (or 9-) methoxy-1, 3-dimethyl-12-thiopyrido [1,2:3,4] -imidazo [1,2-a ] benzimidazol-2 (12H) -one, and then alkaline hydrolysis is carried out to generate esomeprazole impurity H431/41. The invention has simple reaction route, does not relate to the reaction under harsh chemical reaction conditions, does not relate to high-risk chemical reaction process, and is suitable for laboratory trial production of impurity reference substances. |
| priorityDate | 2022-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.