| abstract |
The invention provides an xanthoxylin cyclodextrin inclusion compound and a preparation method thereof, belonging to the field of natural medicinal chemistry. The xanthoxylin cyclodextrin inclusion compound is prepared from xanthoxylin and cyclodextrin as raw materials. In the present invention, hydroxypropyl-β-cyclodextrin is used to clad xanthoxylin to obtain xanthoxylin cyclodextrin clathrate. With the proportioning and preparation method of the present invention, the clathrate has high inclusion rate and stable quality. , the solubility in the water phase is significantly increased, and it has a higher dissolution rate, which is beneficial to improve the bioavailability of xanthoxylin; in addition, the inclusion compound can prevent the oxidation of xanthoxylin and decompose under light, and can significantly improve the bioavailability of xanthoxylin stability. The preparation method of the xanthoxylin inclusion compound is simple, easy to operate, high in efficiency, and suitable for industrial production. |