http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114397290-A

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filingDate 2022-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d96cf3b7f9c475647836ad8d656d71d
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publicationDate 2022-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-114397290-A
titleOfInvention A kind of preparation method of electrochemiluminescence sensor based on encapsulated DNA tetrahedron
abstract The invention relates to a preparation method of an electrochemiluminescence sensor based on a capsule-type DNA tetrahedron. The invention adopts intramolecular luminescence Mn-CIS/Mn-ZnS@TPrA to coat the DNA tetrahedron, designs a label-free electrochemiluminescence sensor, and realizes sensitive detection of mercury ions of environmental pollutants. It is worth noting that the quenching effect caused by the agglomeration of quantum dots is reduced by encapsulating the quantum dots in the DNA tetrahedron, while the Mn‑CIS/Mn‑ZnS@TPrA encapsulation in the DNA tetrahedron is immobilized on the electrode surface, reducing the The hydrophilicity causes rapid dissolution of the material while increasing the biocompatibility of the material. Mn-CIS/Mn-ZnS@TPrA as an intramolecular luminescence mechanism can improve electron transfer efficiency and reduce energy consumption. Utilizing a design that separates the recognition and detection processes, the influence of biomolecules on the signal is reduced. With the recognition and cleavage of the track chain, migration chain, cleavage enzyme and Hg 2+ in the 96-well plate, only the short chain is modified on the electrode surface, which reduces the impedance value and realizes the quantitative sensitivity of Hg 2+ . Riddle. The detection limit was 0.19 pmol/L.
priorityDate 2022-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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