| abstract |
The invention discloses a diketopiperazine derivative, a synthesis method and application thereof, wherein the diketopiperazine derivative has a structure shown as a formula I, wherein R 1 Is hydrogen, C1-C4 alkyl or C2-C3 acyl; r 2 Is hydrogen, C1-C4 alkyl or C2-C3 acyl; r 3 Is formaldehyde group, carbinol group, nitrile group or According to the invention, the marine microorganism derived diketopiperazine metabolite CryD is used as a raw material, and the anti-angiogenesis drug through the Ang2/Tie2 signal transduction pathway is obtained through structure optimization. |