http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114380835-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cfd2149669ec86fe1a628cc3b39fd742 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2022-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ac6f4b058ed14dbdf38c02dcd324d9f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c611028e87f0be29a39fecde30455dc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ebea8ac585a1a32713e74c0925d3ea3e |
| publicationDate | 2022-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114380835-A |
| titleOfInvention | A kind of preparation method of 7-(3,4-dimethoxyphenyl)-2-pyrazolo[1,5-A]pyrimidine carboxylic acid |
| abstract | The invention relates to the technical field of pharmaceutical preparation, in particular to a method for preparing 7-(3,4-dimethoxyphenyl)-2-pyrazo[1,5-A]pyrimidinecarboxylic acid, which specifically comprises the following steps: Under the action of a base, the oxalic acid diester and acetonitrile are subjected to a nucleophilic addition reaction in an organic solvent to generate compound A; under the action of an acid, compound A is subjected to ring-closure reaction with hydrazine in an organic solvent to obtain compound B; 3,4- Under the action of acid, dimethoxyacetophenone reacts with N,N-dimethylformamide dimethyl acetal to obtain compound C; under the action of acid, compound B and compound C undergo ring closure in an organic solvent The reaction produces compound D; under the action of a base, compound D is hydrolyzed to compound E in an organic solvent and water. In the method of the invention, the raw materials are readily available, the cost is low, the process is stable, and the prepared 7-(3,4-dimethoxyphenyl)-2-pyrazo[1,5-A]pyrimidine carboxylic acid has high chemical purity. |
| priorityDate | 2022-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 77.