| abstract |
The invention discloses a mifepristone capsule and a preparation method thereof, comprising mifepristone, a solubilizer, an adhesive, an acidity regulator and a diluent. The preparation method of the mifepristone capsule is as follows: firstly pulverizing the mifepristone, then mixing the pulverized mifepristone with a solubilizer to obtain a mifepristone mixture containing the solubilizer; The non-pristone mixture is mixed with an adhesive, an acidity regulator and a diluent to obtain capsule contents; finally, the capsule contents are filled into empty capsules to obtain mifepristone capsules. The mifepristone capsule prepared by adding a self-made solubilizer in the present invention has a good slow-release effect in the intestinal tract and can significantly improve the bioavailability. |