http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114369092-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_86275eeefdb9bf80d8eb1862aa48055f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C309-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-61 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C309-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-61 |
| filingDate | 2021-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_15a78b3d01717e8404964bf7afeb1a12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b5318729b701780bdb3d5b86d96dd8e8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dda5baf961d2427273d27615857f1eae |
| publicationDate | 2022-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114369092-A |
| titleOfInvention | Tosufloxacin tosylate and preparation method thereof |
| abstract | The invention provides tosufloxacin tosylate and a preparation method thereof, wherein the preparation method comprises the following steps: carrying out amination reaction by using acetic anhydride, triethyl orthoformate, fluorochlorotinate, methanol and 2, 4-difluoroaniline as initial raw materials to prepare tosufloxacin tosylate amino; preparing a tosufloxacin tosylate cyclic compound through a cyclization reaction based on an amine base; preparing a tosufloxacin tosylate substituent by a substitution reaction based on a cyclic compound; and (3) preparing a crude product of the tosufloxacin tosylate by hydrolysis salifying reaction based on the substituent, and refining to obtain the tosufloxacin tosylate. The preparation method disclosed by the invention covers all steps of a synthesis route of the tosufloxacin tosylate, and a complete production chain is formed by designing all steps of the synthesis route, so that the prepared tosufloxacin tosylate has the advantages of low impurity content, high purity and high yield, and meets the high quality requirement of the medicine field on medicines. |
| priorityDate | 2021-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 60.