| abstract |
The invention discloses compounds, compositions and methods of formula (I) for inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway. The compounds, compositions and methods can be used to modulate the immune system for the treatment of diseases amenable to immune system modulation, as well as for the treatment of cells in vivo, in vitro or ex vivo. The present invention also discloses a pharmaceutical composition comprising a Cbl-b inhibitor and a cancer vaccine, and a method for treating cancer using the Cbl-b inhibitor and the cancer vaccine; and a pharmaceutical composition comprising the Cbl-b inhibitor and an oncolytic virus, and methods of treating cancer using Cbl‑b inhibitors and oncolytic viruses. |