http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114342875-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2c27f4a786895417d03d0b1045587100 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-02 |
| filingDate | 2022-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_838e2bac50a7dd4cdba3efa7d7f13a26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4596cb69100b837522b07f02ed7017a7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_10ec6686ab07073f3311342e33191393 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd36502f76970bc6da9cb183679ce42c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_439497d5ea59123d0c0c0dd8264b37ce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9bfc0312182fd84b38f5c5f8766c9c66 |
| publicationDate | 2022-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114342875-A |
| titleOfInvention | A new method for establishing an animal model of gestational diabetes mellitus |
| abstract | The invention discloses a method for establishing a new gestational diabetes animal model. 6-week-old C57BL/6J female mice are divided into 4 groups, of which two groups of C57BL/6J female mice are given basal feed for 4 weeks; the other two groups of C57BL /6J female mice were fed a high-fat diet containing 45% fat for 4 weeks to establish a diet-induced obesity model; after group feeding for 4 weeks, C57BL/6J female mice were co-mated and mated to observe pregnancy; From the 7th day of gestation, the insulin receptor antagonist S96120nmol/kg was subcutaneously injected every day to establish an animal model of gestational diabetes mellitus. Different from the previous model of gestational diabetes mellitus mice or rat models with long modeling time, low success rate, high animal mortality, and damage to offspring due to modeling methods, the present invention establishes a stable model similar to human pathogenesis. , Reliable mouse model, and the modeling time is short, the success rate is high, and there is no obvious toxic effect on the mother mouse and embryo, which is in line with the characteristics of human gestational diabetes. |
| priorityDate | 2022-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 97.