| abstract |
The present invention relates to an immune microvesicle complex and its use. The immunomicrovesicle complex (IMC) according to the present invention comprises antibody-conjugated microvesicles, wherein the microvesicles have excellent stability and excellent antibody binding strength, and it was confirmed that when treated with high-intensity focused ultrasound (HIFU) When the immune microvesicle complex was used, the anti-tumor effect was significantly enhanced and showed an immune-enhancing effect. Therefore, the immune microvesicle complexes according to the present invention are expected to improve the delivery efficiency of conjugated antibodies and can be used in the diagnosis and treatment of cancer, and exhibit various functions in the field of immunotherapy, including contrast effect, half-life improvement, improved drug delivery, Lymphocyte concentration effects, cancer immunotherapy and induction of immunotherapy using ultrasound. |