| abstract |
The invention provides a fusion protein. The fusion protein comprises: a VEGF antagonist antibody comprising a Fab region and an Fc region, and IL-10. The inventor finds that the killing effect of the fusion protein on the tumor is obviously better than the combination of a single VEGF antagonistic antibody and a single empty target antibody-IL-10 fusion protein, and the synergy of the VEGF antagonistic antibody and the IL-10 fusion protein is obvious. |