http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114315797-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 2022-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114315797-B |
| titleOfInvention | A kind of preparation method of high crystal purity esomeprazole magnesium dihydrate crystal |
| abstract | The invention discloses a preparation method of high crystal purity esomeprazole magnesium dihydrate crystal, belonging to the technical field of medicinal chemistry. The described dropping of the solubilizing agent and crystallizing, the temperature of the esomeprazole magnesium intermediate is controlled to 15-25°C, the solubilizing agent is added under stirring, and the crystallizing is carried out at -5°C to 20°C, Control the crystallizing time to be 4-8h, and obtain the esomeprazole magnesium hydrate of the transition state crystal form after the crystallisation is completed; the drying and controlling the water content, the esomeprazole magnesium hydrate of the transition state crystal form is obtained The hydrate is dried; the esomeprazole magnesium dihydrate crystal prepared by the preparation method has high crystal purity, narrow particle size distribution, good fluidity and low magnesium content. |
| priorityDate | 2022-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.