| abstract |
The invention belongs to the technical field of drug synthesis processes, and particularly relates to a preparation method of carbasalate calcium. The method synthesizes the carbasalate calcium by taking the aspirin, the urea, the calcium chloride, the water, the ethanol and the triethylamine as raw materials, avoids the use and the generation of explosive substances, avoids the use of catalysts and ammonia gas, liquid ammonia or ammonia water in the reaction process, simplifies the production process, is easy to recycle the raw materials and reduces the production cost; the reaction and post-treatment processes are simple, and the DCS interlocking device is adopted to control the dropwise addition of the triethylamine, so that the reaction safety is improved, the method is a safe, environment-friendly, green, efficient, energy-saving and economic synthesis route, and the product obtained by the method is high in yield and suitable for large-scale industrial production. |