http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114306321-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0e19f4be0158b0f34a8865653cb54fc4 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-353 |
| filingDate | 2021-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04819151e08819923582a1bb4d3923ed http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8547ea31f98ddbfaefe7b9117557c192 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_55e863308e7f36975306292958f7d1ff http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0792622f01697eb247a6f54f23c439bc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3109365c2981befedc95a1c78f3ab1a4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a2d55ff2497eeb1783919bf18a2da24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0298326856ddc088c8b50388b294337d |
| publicationDate | 2022-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114306321-A |
| titleOfInvention | Application of kurarinone in preparation of medicine for preventing and treating Parkinson's disease |
| abstract | The invention discloses an application of kushenketone in preparing a medicine for preventing and treating Parkinson disease, wherein 1-methyl-4-phenyl-1, 2,3, 6-tetrahydropyridine hydrochloride (MPTP) is adopted for molding, the motor capacity of a PD mouse is reduced, the levels of intracerebral Dopamine (DA) and metabolites thereof, namely 3, 4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), are reduced, and the level of Tyrosine Hydroxylase (TH) is reduced. The kurarinone (kurarinone) is given to inhibit the activity of soluble epoxide hydrolase (sEH), so that the content of Dopamine (DA) and metabolites thereof, namely 3, 4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in brain is increased, and the MPTP-induced PD is further improved. |
| priorityDate | 2021-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 133.