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filingDate 2022-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da9a4021947ea674e42ca5f8ab584b1a
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publicationDate 2022-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-114305792-A
titleOfInvention Ligament regeneration scaffold with layer-by-layer induction performance and preparation method thereof
abstract The invention discloses a ligament regeneration scaffold with layer-by-layer induction performance and a preparation method thereof. The ligament regeneration bracket has a multilayer composite structure and is formed by overlapping and compounding a gradient degraded micro-fiber reinforcing layer and an oriented nanofiber inducing layer; the nanofiber induction layer is prepared from a high polymer material and bioactive components through electrostatic spinning. The preparation method comprises the following steps: preparing a micron fiber reinforced layer, preparing a nanofiber inducing layer, and then compounding layer by layer to prepare the ligament regeneration scaffold with the layer-by-layer inducing performance. Based on the regulation and control of the gradient degradation structure, the gradient degradation of the micron fiber reinforced layer is realized while the initial mechanical strength is ensured, and the nanofiber inducing layer is exposed layer by layer to accurately regulate and control the infiltration and remodeling of the internal tissues of the stent, so that the scaffold can be used for ligament/tendon regeneration reconstruction treatment.
priorityDate 2022-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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