| abstract |
The invention discloses citicoline spherical crystals and a preparation method thereof; the preparation method comprises the following steps: after the mixed solvent of citicoline-water-A solvent and bridging agent are mixed, citicoline seed crystal and A solvent are added in turn to precipitate crystals, and the spherical crystal has good stability, round and smooth particles, uniform granularity, good fluidity and high bulk density. |