| abstract |
The present invention provides the application of a circular RNA CircOGDH as a therapeutic target of acute ischemic stroke, in particular to the preparation of molecular targeted drugs for preventing and/or treating acute ischemic stroke, and the preparation of acute ischemic stroke Stroke neuroprotective agents. The circular RNA CircOGDH of the present invention is highly expressed in ischemic and hypoxic neurons after the onset of acute ischemic stroke. By knocking down CircOGDH, neuronal apoptosis can be alleviated. Therefore, CircOGDH is a neuron after the onset of acute ischemic stroke. Potential protective targets of apoptosis. The invention provides a new target for developing neuroprotective drugs for acute ischemic stroke. |