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filingDate 2020-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99ab4d1c589f4bcdbea5b09b8aac7113
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publicationDate 2022-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-114272255-A
titleOfInvention Use of ginseng flavonoid glycosides in the preparation of angiogenesis-promoting drugs
abstract The invention relates to the technical field of medicine, and relates to a new use of ginseng flavonoid glycosides in pharmacy, in particular to the use of ginseng flavonoid glycosides alone or as an active ingredient in the preparation of drugs for treating acute or chronic diseases accompanied by insufficient angiogenesis, or for promoting angiogenesis. use. The invention adopts VEGF receptor inhibitor to induce zebrafish angiogenesis deficiency model and human vein endothelial cell injury model, simulates the pathological state of disease angiogenesis deficiency, studies the effect of ginseng flavonoid glycosides in promoting angiogenesis, and finds that ginseng flavonoid glycosides promote blood vessel formation The neonatal effect is obvious, and the effective rate is more than 90%, and its mechanism of action is related to the expression of VEGF receptor and apoptosis. It shows that ginseng flavonoid glycosides have effective angiogenesis-promoting effect, and are suitable for treating diseases related to insufficient angiogenesis. It has a wide range of sources and low toxicity, provides a new way for the treatment of diseases with insufficient angiogenesis, and is a potential preparation of angiogenesis drugs.
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