http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114262692-A
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ea95b89ec0cea21268eb3e804df6f68 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-861 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-761 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11 |
filingDate | 2021-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_521f584db9efee5f7c2b8e767560caf2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f250ed967b6661dc7c5a96c0d78603f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8902b0db0d5b1a457f51be4b734718e4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f2622a6e559037ac56cda5fe2f4ff67 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33ae2e6cb79d2a5183c122af58e0a569 |
publicationDate | 2022-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-114262692-A |
titleOfInvention | Oncolytic adenovirus recombinant carrying TMVP1 and HSV-TK, and construction method and application thereof |
abstract | The invention discloses an oncolytic adenovirus recombinant carrying TMVP1 and HSV-TK, a construction method and application thereof, and belongs to the technical field of medical genetic engineering. The invention deletes 27 basic groups of 920nt-946nt region in E1A conservative sequence 2 region of human 5 type adenovirus gene, inserts gene sequence coding tumor targeting peptide TMVP1 in 19641nt-19655nt region of Hexon hypervariable region 5, simultaneously deletes E3 region in 29477nt-29714nt region of ADP gene to form deletion region, inserts full length coding sequence coding HSV-TK gene in the deletion region and introduces Cla1 enzyme cutting site. The invention also discloses a construction method and application of the oncolytic adenovirus recombinant. The oncolytic adenovirus recombinant carrying TMVP1 and HSV-TK has ideal targeting effect and strong killing effect. |
priorityDate | 2021-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 339.