http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114259493-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1e2efaa482535230172df5e863f36c00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 |
| filingDate | 2021-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae0a1ac4de35930c6b10e246f71251dd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e683a1a348136b9e3d3717d44da03e55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_65f356df448c46ae885f5e1fe622e61b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4b0c609bbc4fd5a995613e67e209fdb8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53eb56b61be3cd0a6a0309b80d8bb56d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a0a72ef316345c2b12549057034fe8b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67d2c931256c0a4ca89b487aa027b885 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_369c155938d0200adad4e5b2d7f87a22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ca26385de7e5566c7b8c8b7d7f694f6 |
| publicationDate | 2022-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114259493-A |
| titleOfInvention | Application of antibiotic adjuvant and analogue for inhibiting salmonella efflux pump |
| abstract | The invention belongs to the field of veterinary drug preparation and application, and particularly relates to an antibiotic adjuvant for inhibiting a salmonella efflux pump and application of the antibiotic adjuvant and analogues. The AcrB protein is docked with potential candidate drugs by using a molecular docking method, domperidone is taken as an optimal candidate efflux pump inhibitor, and the optimal proportion of the domperidone for enhancing the antibacterial activity of enrofloxacin against drug-resistant salmonella and drug-resistant escherichia coli is confirmed by a chessboard method; the inhibitory activity of domperidone on the salmonella AcrAB-TolC pump was confirmed by positive inhibitors of the AcrAB-TolC pump. And further confirms the function of domperidone in inhibiting the formation of salmonella biomembranes and inhibiting the pathogenicity of salmonella multi-hosts. The invention proves that when domperidone is used together with antibacterial drugs, the drug resistance of drug-resistant salmonella and escherichia coli can be effectively reversed, and the domperidone has obvious effects on inhibiting biofilm formation and pathogenicity. |
| priorityDate | 2021-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 123.