| abstract |
The invention relates to a preparation method of a drug-loaded mesoporous calcium silicate modified PMMA bone cement, its product and application, including the preparation of mesoporous calcium silicate, the preparation of drug-loaded mesoporous calcium silicate, and the gelatin coating treatment and modified PMMA bone cement preparation. The invention uses the drug-loaded mesoporous calcium silicate coated with gelatin as a drug carrier and a filler, which can promote the biocompatibility and osteogenic ability of the PMMA bone cement and reduce the elastic modulus of the bone cement; The dissolution rate in water, the cross-linking and fixation of biologically active drugs in mesopores, and under the protection of gelatin coating, can avoid the inactivation of polymerization and exothermic heat, which expands the clinical application scope of this type of bone cement. |