| abstract |
The invention belongs to the field of pharmaceutical preparations, and relates to a brain glioma whole region targeted nanometer drug delivery system and a preparation method and application thereof. The drug delivery system includes a double-layer targeting molecule, a drug and a foaming agent, the targeting molecules are R9 polypeptide and hyaluronic acid HA, the foaming agent is 1-bromosevoflurane, and the drug and the foaming agent are co-packaged in In the nanocarrier; the targeting molecule R9 polypeptide is covalently linked on the surface of the nanoparticle; the targeting molecule HA is wrapped in the outer layer of the R9 polypeptide through electrostatic action. In the present invention, the outer layer targeting molecule HA is targeted and accumulated in the border region of gliomas with high expression of hyaluronidase Hyal-2 and CD44. The high affinity of the tumor cell membrane further bidirectionally delivers the drug to the core and infiltrating areas of glioma. After the drug is accumulated, HIFU irradiation is given to induce the instantaneous and full release of the drug, which can greatly improve the core area, marginal area and infiltration of glioma. area of drug concentration. |