| abstract |
The invention belongs to the field of sustained-release preparations, in particular to an alfuzosin hydrochloride sustained-release preparation and a preparation method thereof. The alfuzosin hydrochloride sustained-release preparation provided by the present invention comprises drug-carrying pellets, a sustained-release coating layer, and a pharmaceutical excipient layer, wherein the drug-carrying pellets comprise alfuzosin hydrochloride, filler, plasticizer, Sustained-release matrix material, lubricant, stabilizer; sustained-release coating layer includes film-forming material, plasticizer, lubricant, and purified water. The pharmaceutical excipient layer includes fillers, disintegrants, flavoring agents, lubricants and glidants. Alfuzosin hydrochloride orally disintegrating tablet is characterized in that it can disintegrate or dissolve without water in the oral cavity. It has the characteristics of convenient administration, fast absorption and high bioavailability, which can improve the compliance of patients with medication and increase the clinical application of doctors. The choice of medication for different patients. |