http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114195790-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2021-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2023-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2023-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114195790-B |
| titleOfInvention | A kind of synthetic method of ibrutinib |
| abstract | The present invention relates to the technical field of pharmaceutical synthesis, in particular to a synthetic method of ibrutinib, comprising the following steps: (1) uniformly mixing compound III with a solvent, adding triphenylphosphine, compound IV and azo Compound, the reaction mixture was stirred overnight, filtered, concentrated and purified to obtain Compound II; (2) Compound II was mixed uniformly with the solvent, nitrogen replacement protection was added, and 10% palladium carbon was added to keep the reaction mass stirring for 12 hours under hydrogen pressure . The reaction mass was concentrated, the resulting residue was dissolved in dichloromethane, triethylamine was added, followed by acryloyl chloride, and the reaction was terminated after 3 hours. Compound I, i.e. ibrutinib, was obtained after post-treatment. The method has a total yield of more than 83 percent, a purity of more than 99 percent, a simple reaction process, mild reaction conditions and no environmental pollution, and is suitable for industrialized large-scale production of ibrutinib. |
| priorityDate | 2021-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 57.