http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114195741-A
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8679b30b365eaba9e965a281ab6f9f56 |
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D301-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D303-36 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D303-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D301-03 |
filingDate | 2021-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_faebd98b6f2ee5d98a85a2978fb47618 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c7045c1cf8503711833421cd8ee572f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce34a330f160f165952729fc187cdde8 |
publicationDate | 2022-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-114195741-A |
titleOfInvention | Preparation method of carfilzomib key intermediate isomer |
abstract | The invention provides a preparation method of a carfilzomib key intermediate isomer, which is characterized by comprising the following steps: (1) BOC-D-leucine (SM) is activated by pivaloyl chloride and condensed with morpholine under the action of N-methylmorpholine to obtain a compound 1; (2) reacting the compound 1 with a Grignard reagent under the action of isopropyl magnesium chloride to obtain a compound 2; (3) and oxidizing the compound 2 with sodium hypochlorite to obtain a compound 3 and a compound 4. The method can obtain isomers with high purity, and the purity can meet the requirements of structure identification, impurity spectrum research and methodology verification. Has important significance for the quality research and the quality control of the carfilzomib key intermediate compound 6 and the finished carfilzomib. |
priorityDate | 2021-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.