| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6a90a6154c527cd7c7a36b7660c08f81 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2602-20 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-343
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C201-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-608
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C201-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C309-29
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C205-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-343
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-32 |
| filingDate |
2021-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5f9891d32c57255b41bc2bd5d30f6b2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61e2406c860e926f056a327c4b9bb184
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a09d7942e0a70a588afe863473f1e0a5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34cedcb63b371c1247e020e9cc8d96ae
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_105c4ccf7e2931fbcd60e70ce7282554 |
| publicationDate |
2022-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-114195661-A |
| titleOfInvention |
Preparation method of milobalin besylate |
| abstract |
The invention relates to the technical field of organic synthesis, in particular to synthesis of a medicine of benzene sulfonic acid milobalin bulk drug for treating neuropathic pain, wherein a compound in a formula (3) reacts with dimethoxy phosphono acetic acid tert-butyl ester to obtain a compound in a formula (4); adding the compound shown in the formula (4) and nitromethane under the action of DBU to obtain a compound shown in a formula (5); hydrolyzing the compound shown in the formula (5) under an acidic condition to obtain a compound shown in a formula (6); resolving with (S) - (-) -N-benzyl-alpha-methylbenzylamine to obtain the compound of formula (7); nitro reduction to obtain a compound shown in a formula (8); reacting with benzene sulfonic acid to obtain the drug compound of the milopaline benzene sulfonate. The invention provides a simple and convenient industrial production route for the medicine milobalin for treating neuralgia, and has the advantages of simple reaction operation and lower cost. |
| priorityDate |
2021-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |