| abstract |
The invention discloses a polyetheretherketone implant with controlled drug slow release and a preparation method thereof. The implant includes a drug-loaded region and a solid region, the solid region including a first polyetheretherketone substrate, the drug-loaded region including a second polyetheretherketone substrate, a drug-loaded vehicle, and a load through the drug-loaded vehicle A drug or active factor on a second polyetheretherketone substrate; the second polyetheretherketone substrate has interconnected concave pores less than or equal to 10 μm, and the strength of the first polyetheretherketone substrate is sufficient to make the The implant retains its original structure during use; the first polyetheretherketone base and the second polyetheretherketone base are printed by laser selective sintering. Using the unused porosity to control the slow release rate and time of the drug or active factor, it solves the problem that the existing surface coating drug-carrying technology is easy to fall off, the slow release time is too fast, and the porosity of the conventional pore-making technology is uncontrollable and introduced. Technical problems with harmful groups, etc. |