| abstract |
The invention relates to a synthesis method of 5-aminolevulinic acid hydrochloride, and specifically relates to a method for synthesizing a target product by amination reaction and hydrolysis reaction of 4-bromo-4-ethyl valerate serving as a raw material. The synthesis method disclosed by the invention is mild in reaction conditions, high in atom utilization rate and high in total yield of 47%, and the process route disclosed by the invention does not use heavy metal reagents with high toxicity and high price, is high in safety and accords with the green chemical concept. |