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filingDate 2020-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47eaa82b97a99e9675b7185f42452b01
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publicationDate 2022-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-114159623-A
titleOfInvention A kind of self-anticoagulation elastomer material and preparation method thereof
abstract The invention belongs to the technical field of polymer material synthesis, and relates to a self-anti-coagulation elastomer material and a preparation method thereof. The molecular structure of the elastomer material of the present invention is simultaneously grafted with anticoagulant active ingredients such as a sulfonic acid group (-SO 3 - ) and an anti-platelet agent. Polyol sulfonic acid sodium salt is introduced, and -SO 3 -modified prepolymer is obtained by esterification polymerization; further , a carboxyl-containing antiplatelet reagent is introduced into the -SO 3 -modified prepolymer, and -SO 3 - is obtained by esterification and polymerization A prepolymer double - modified with an antiplatelet agent; the self-anticoagulant elastomer material can be obtained by curing and crosslinking the obtained prepolymer double - modified with an antiplatelet agent. The elastomer material of the present invention has dual-channel anticoagulation properties that simultaneously inhibit the coagulation cascade reaction and platelet activation, and has good biocompatibility and biodegradability; the preparation method of the self-anticoagulation elastomer material is biologically safe and has no Risk of residual toxic reagents.
priorityDate 2020-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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