| abstract |
The present disclosure relates to tetrahydropyridopyrimidinedione derivatives, their preparation methods and their applications in medicine. Specifically, the present disclosure relates to a tetrahydropyridopyrimidinedione derivative represented by the general formula (IM), its preparation method, a pharmaceutical composition containing the derivative, and its use as a therapeutic agent, especially Use as a Myosin inhibitor and in a medicament for the treatment of hypertrophic cardiomyopathy (HCM) or heart disease with pathophysiological features associated with HCM. |