| abstract |
The invention belongs to the field of biomedicine, and provides a novel ionizable lipid for nucleic acid delivery and an LNP composition thereof, which can efficiently and stably deliver biologically active substances to target cells or organs. The mRNA LNP prepared by using the lipid compound of the present invention as the cationic lipid has better stability and transfection efficiency, and can cause a higher specific antibody response in experimental animals. |