| abstract |
The invention belongs to the field of biomedicine, and relates to the use of PYCR1 gene as a target in the preparation of products for the treatment and/or diagnosis of esophageal cancer. The invention adopts RNAi method to down-regulate the expression of PYCR1 gene, which can significantly inhibit the proliferation, growth, migration and infiltration of esophageal cancer cells, promote the apoptosis of cancer cells, and can effectively control the growth process of esophageal cancer. The siRNA or the nucleic acid construct comprising the siRNA sequence and the lentivirus provided by the present invention can specifically inhibit the proliferation rate of esophageal cancer cells, promote the apoptosis of esophageal cancer cells, inhibit the cloning of esophageal cancer cells, inhibit the invasion of esophageal cancer cells, and inhibit esophageal cancer cells Cell transfer, inhibiting the growth of esophageal cancer, so as to be used for the treatment and detection of esophageal cancer, and have broad application prospects. |