| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5f336d80f85b915ccbf4da751234996b |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-05
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-15043
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-206
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0381
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-107
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-30 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-907
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1137
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0276
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1007 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-867
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 |
| filingDate |
2021-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a8b8fd7e336c5b76dde2c6d681c3ab3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4160e8f9158dd2e9a1ecc4a2a281e32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3f1b91cf26fe3b3493750f2e99e11d8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fda39b0ef9e58e6b5362ad33672bec13 |
| publicationDate |
2022-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-114134177-A |
| titleOfInvention |
Construction method and application of mouse model of knockout Setd5 and mouse model against acute T lymphocytic leukemia |
| abstract |
The invention discloses a mouse model for knocking out Setd5 and a construction method and application of a mouse model against acute T lymphocytic leukemia. The invention uses CRISPR-Cas9 technology to insert Loxp sites at both ends of the mouse SETD5 gene, and combines Vav-Cre and Mx1-Cre to establish a mouse model for knocking out SETD5 in blood cells. Using lentivirus-mediated gene transfer technology, Notch1 mutation was introduced into Setd5-deficient hematopoietic stem/progenitor cells, and a mouse model of acute T lymphoblastic leukemia was obtained by transplantation. The SETD5 knockout physiology and disease mouse model of the present invention can quickly and effectively conduct qualitative and quantitative evaluation of hematopoietic stem cell function and potential drugs of acute T lymphocytic leukemia, and has a good clinical application prospect. |
| priorityDate |
2021-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |