http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114134112-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ec4510bcb289ba1a17a2d07ab53e3d66 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-1114 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2509-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-515 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-51 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0636 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-067 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0694 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0783 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-09 |
| filingDate | 2021-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08d685f1c102fd97e16f0d05dc74f52a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_530de651aef97192550d9a7f9c53f1ab http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b295479f111ca6c2729f16dd228a7234 |
| publicationDate | 2022-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114134112-A |
| titleOfInvention | Kit and method for establishing in-vitro research model of autoimmune hepatitis |
| abstract | The invention belongs to the technical field of research on medical experimental models, and discloses a kit and a method for establishing an in-vitro research model of autoimmune hepatitis, aiming at the importance of an in-vitro research model of T cell mediated hepatocyte injury on the research on the autoimmune hepatitis. The kit comprises: jurkat human T lymphocyte leukemia cells, HL-7702 human liver cells, a special culture medium for co-culture of the T cells and the liver cells, a human CD3/CD28T cell activator, cell digestive juice and sterilized PBS solution. The method comprises the steps of co-culturing T cells and liver cells in a special culture medium, establishing a T cell/liver cell co-culture system, activating the T cells through the induction of a T cell activator, and causing liver cell damage through the expression of cytokines by the T cells, thereby partially simulating the pathogenesis of human autoimmune hepatitis in vitro. The method has the characteristics of one-stop type, quickness and stability, and can reduce the influence of species difference on subsequent experimental results. |
| priorityDate | 2021-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.