| abstract |
The invention discloses a low molecular weight acetylated hyaluronate and a preparation method and application thereof, belonging to the technical field of biochemical industry. Wherein, the degree of acetyl substitution is 1.9-4.0, and the intrinsic viscosity is 0.02-0.11dl/g, which is prepared from low-molecular-weight hyaluronic acid or its salt with an average molecular weight of 800-4500Da, and the preparation method: under the protection of inert gas, The low molecular weight hyaluronic acid or its salt is added to the mixed solution of acetic acid and acetic anhydride, and the concentrated sulfuric acid catalyst is added to carry out the acylation reaction; after the reaction, the reaction solution is added to the ether solvent for crystallization, filtration, and washing; the solid is collected Disperse in water, adjust pH with lye, and dry to prepare. The invention uses low-molecular-weight hyaluronate as a raw material, the acetylation degree is moderate, and the obtained acetylated hyaluronate has more significant moisturizing, lipophilic and skin-friendly, and is widely used in lotions, essences, lipsticks and other cosmetics field. |