http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114129773-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-216 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2420-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2400-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-606 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-404 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-412 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-02 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-54 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-54 |
| filingDate | 2021-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114129773-B |
| titleOfInvention | A titanium implant with bone-promoting performance on its surface and its preparation method |
| abstract | The incidence of osteoporosis is high in the elderly, and the commonly used bone implants lack osseointegration, which can easily lead to loosening and infection. The invention finds through computer screening combined with cell and animal experiments that the antimicrobial drug mecillin has the effect of promoting osteogenesis, and the antibacterial drug mecillin is loaded on the surface of the bone implant to prepare a drug-loaded bone implant with both osteogenesis and antibacterial effects. The invention also discloses a preparation method of the above-mentioned drug-loaded bone implant, which includes the following steps: 1) pretreating the matrix of the bone implant to obtain a surface morphology of micro-nano structure on its surface; After the pretreatment of the body matrix, the bone implant is exposed to the dopamine solution for a period of time to form a polydopamine coating on its surface, and then the bone implant is contacted with a solution containing mecillin to utilize the excellent polydopamine layer on the surface of the bone implant. 3) Rinse the material with deionized water and dry it naturally. |
| priorityDate | 2021-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.