| abstract |
The present invention provides (R)-4-(1-((3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)sulfonyl)-1-fluoroethyl)-N Novel polymorphic form of -(isoxazol-3-yl)piperidine-1-carboxamide (I-491) useful for the treatment of cardiac diseases including systolic dysfunction, dilated cardiomyopathy (DCM), radioactivity Heart failure with preserved blood fraction (HFrEF) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. Synthesis and characterization of polymorphs, and methods for treating systolic dysfunction, DCM, HFrEF, and other forms of heart disease are described. |