| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5c732ed7dd030239e2e90538d54b1d8d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-10 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6893
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-53 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 |
| filingDate |
2020-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_edcf9541ca282fcf55a70e715ea6a37c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95ea9d286f32a4c67266dfce01307a92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_caa9ea0fc887120c69707fe544d5789c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a25dd85fc747cbb16e363fffbd4afac3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_150e211a352c594fedd4228a65b0c3e3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8743e46239420ccf9ea9f5bae0dc970e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0da5e88eaeac25bdb62f0fcf9fe51057
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c2ab136b4e63155f050f4d1c961d7e5c |
| publicationDate |
2022-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-114113572-A |
| titleOfInvention |
Use of Piezo1 inhibitor for the manufacture of a medicament for the treatment or prevention of ectopic ossification |
| abstract |
The invention belongs to the field of biological medicines, and relates to application of a Piezo1 inhibitor in preparation of a medicine for treating or preventing ectopic ossification. The invention discovers that the expression of the ectopic new bone formation part Piezo1 in DBA/1 and SMTS mouse models is high for the first time, and the mouse ectopic bone formation is obviously reduced after GsMTx4 is adopted to inhibit Piezo 1. The invention also provides application of the detection reagent of Piezo1 in preparing a detection reagent or a kit for ectopic ossification and application of the Piezo1 inhibitor in preparing a medicament for treating or preventing ectopic ossification. Taking the example of ankylosing spondylitis ectopic ossification, GsMTx4 has a good inhibition effect. |
| priorityDate |
2020-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |