| abstract |
The invention provides an ACOT7-NPHP4 fusion gene, and application and a detection kit thereof, wherein the fusion gene sequence is shown as SEQ ID NO. 1. The invention firstly discovers and identifies the existence of a new fusion gene ACOT7-NPHP4 in acute lymphocytic leukemia, evaluates that ACOT7-NPHP4 can be used as a specific molecular marker of the acute lymphocytic leukemia, and further develops a kit which can be clinically used for diagnosing and detecting Minimal Residual Disease (MRD) of a patient. The kit carries out absolute quantification on the ACOT7-NPHP4 fusion gene in the body of an acute lymphocytic leukemia patient by using Taqman probe real-time fluorescent PCR, has good detection specificity, high sensitivity, simple, convenient and efficient method and low cost, and can meet the clinical diagnosis and treatment requirements. |