| abstract |
The invention discloses a novel near-infrared second-region aggregation-induced luminescent material, a preparation method and an application, and the general formula of its chemical structure is: R is independently selected from and One of them has a D-π-A-π-D structure, and 6,7-diphenyl-[1,2,5]thiadiazole[3,4-g]quinoxaline in the molecular structure is used as A strong electron acceptor, benzo[c]thiophene acts as an electron-rich donor and π-bridge on the one hand, and acts as a large sterically hindered group to increase the dihedral angle with the acceptor element, making the overall molecular skeleton More twisted to ensure its aggregation-induced luminescence properties, the strong D‑A effect can prolong the absorption/emission wavelength. The synthesis route of the invention is simple, the cost is low, the biocompatibility is good, the fluorescence quantum yield that can be used for biological imaging and the good photothermal conversion efficiency are combined, and the photothermal ablation tumor can be used for multimodal imaging navigation. In addition, photothermal therapy can cause immunogenic death of cancer cells and induce the body's immune stress response, which can be used for photothermal synergistic immunotherapy. |