http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114105980-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_757d618b148706bef2dd534eca5f6664 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-16 |
| filingDate | 2021-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_51a5b7907871c70cbc916224a97240d3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_317cfc728a9d1ad3b3fd54c467655a6a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_259ae427d75099f90e8b23062b73a8a6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_333143d35e3d0a08f744f3455ad47cc9 |
| publicationDate | 2022-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114105980-A |
| titleOfInvention | Preparation method of rumepilone intermediate compound and rumepilone intermediate compound |
| abstract | The invention is suitable for the technical field of drug synthesis, and provides a preparation method of a rumepilone intermediate compound and the rumepilone intermediate compound; the invention utilizes Ir-ZhaoPhos asymmetric hydrogenation to construct the chiral compound 2, has high enantioselectivity, high conversion efficiency (S/C is 5000-; further derivatization is carried out on the obtained chiral compound 2a, benzene ring bromination treatment, copper catalysis C-N coupling, debromination and amide reduction are carried out to obtain the rumepilone key intermediate 7, and the synthesis of the rumepilone key intermediate 7 by the compounds 2b, 2C and 2d does not comprise bromination and debromination steps, so that the method is economic and environment-friendly. |
| priorityDate | 2021-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 148.