http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114105859-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0808 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-52 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-083 |
| filingDate | 2022-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114105859-B |
| titleOfInvention | Synthetic method of 6, 6-dimethyl-3-azabicyclo [3.1.0] hexane |
| abstract | The invention relates to the technical field of drug intermediates, in particular to a 6, 6-dimethyl-3-azabicyclo [3.1.0]]Hexane synthesis method using 6, 6-dimethyl-3-oxazole cyclo [ 3.1.0%]The 6, 6-dimethyl-3-azabicyclo [3.1.0] is prepared by using hexane-2-ketone as raw material and through hydrolysis, oxidation, dehydration, ammonolysis cyclization and reduction]Hexane, said 6, 6-dimethyl-3-oxazolo cyclo [3.1.0]Hexane-2-ones of the formula The compound shown as 6, 6-dimethyl-3-azabicyclo [3.1.0]Hexane is of the formula The specific synthetic route of the compound is as follows: (ii) a The invention has the advantages that: the method has the advantages of cheap and easily obtained starting materials and obtained key intermediate Is cis-form, can close the ring at room temperature, avoids the high temperature condition of 200 ℃, has simple post-treatment of an intermediate, less three-waste pollution, low energy consumption and low environmental cost, and is suitable for industrial production. |
| priorityDate | 2022-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 113.