http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114085376-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-31 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-645 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G69-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G69-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2878 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2818 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G69-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G69-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-44 |
| filingDate | 2021-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114085376-B |
| titleOfInvention | A kind of polypeptide and its preparation method, bispecific antibody and its application |
| abstract | The invention relates to the field of biotechnology, in particular to a polypeptide, a preparation method thereof, a bispecific antibody and applications thereof. The polypeptide is an Fc-binding polypeptide and can be used for universal, simple and convenient connection of monoclonal antibodies to prepare bi/multispecific antibodies. The present invention utilizes polyglutamic acid (PGLU) or polyaspartic acid (PASP) side carboxyl group to bond Fc-III-4C polypeptide with generally high affinity to immunoglobulin (antibody) constant region (Fc) to prepare multivalent Fc Combined with the polypeptide PGLU-Fc-III-4C or PASP-Fc-III-4C, the multivalent Fc-binding polypeptide can react with a variety of monoclonal antibodies in different ratios in aqueous solution to obtain bi/multispecific antibodies. The bi/multispecific antibody preparation method has the following advantages: the bi/multispecific antibody is prepared by direct incubation in a water environment, the reaction conditions are mild, and the activity of the monoclonal antibody can be retained to the greatest extent; it is simple, efficient, and the monoclonal antibody ratio It is controllable, universal, and has industrialization prospects. |
| priorityDate | 2021-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 259.