| abstract |
The invention discloses a gastric flotation agent for treating Helicobacter pylori infection, and belongs to the technical field of medicine. Specifically, the gastric buoyant comprises a drug core, an intermediate layer surrounding the drug core, and a floating layer bound outside the intermediate layer; wherein the drug core contains IgY antibody and suitable pharmaceutical excipients, including adhesive agent and lubricant; the intermediate layer includes microcrystalline cellulose, polyethylene glycol and crospovidone; the floating layer includes sodium methylcellulose, sodium bicarbonate, binder and lubricant. The invention also provides the preparation method of the gastric floatation agent and its application in the preparation of a medicine for treating Helicobacter pylori infection. The gastric flotation agent provided by the invention can enhance the residence time of the IgY antibody in the stomach, thereby enhancing the curative effect of the IgY antibody, and provides a new idea for the prevention and treatment of Helicobacter pylori. |