| abstract |
The invention discloses an application of TRPV1 in screening or preparing a medicament for preventing, relieving and/or treating liver diseases, belonging to the field of gene function and application. According to the invention, C57/BL mice with TRPV1 gene overexpression and knockout are taken as experimental objects, and through researches on an acute liver injury model, a hepatic fibrosis model, a non-alcoholic fatty liver model and an alcoholic fatty liver model, the results show that compared with a control group of mice, the liver injury of TRPV1 gene overexpression mice is obviously inhibited, and the liver function is obviously improved, while compared with wild type mice, the pathological liver injury of TRPV1 gene knockout mice is obviously aggravated, and the liver function is obviously worsened. Aiming at the functions of the TRPV1, the specific agonist or the overexpression system thereof can promote the TRPV1 gene expression to intervene in liver diseases such as liver inflammation and liver fibrosis. |